PKC mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle
نویسندگان
چکیده
D. K. Bowles, K. K. Maddali, V. C. Dhulipala, and D. H. Korzick Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri; Intercollege Program in Physiology, The Pennsylvania State University, University Park; and Resources and Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania
منابع مشابه
PKCdelta mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle.
Sex hormone status has emerged as an important modulator of coronary physiology and cardiovascular disease risk in both males and females. Our previous studies have demonstrated that testosterone increases protein kinase C (PKC) delta expression and activity in coronary smooth muscle (CSMC). Because PKCdelta has been implicated in regulation of proliferation and apoptosis in other cell types, w...
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AIMS Previous studies from our laboratory have demonstrated that testosterone increases coronary smooth muscle protein kinase C delta (PKC delta) both in vivo and in vitro and inhibits coronary smooth muscle proliferation by inducing G(0)/G(1) cell cycle arrest in a PKC delta-dependent manner. The purpose of the present study was to determine whether endogenous testosterone limits coronary neoi...
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